ABC’s General Hospital Spoilers for the Week of September 22–26, 2025: A Storm of Resurrections, Farewells, and Forbidden Truths in Port Charles

The halls of General Hospital are no stranger to emotional upheaval, but the upcoming week of September 22 through September 26 promises seismic shifts that will reshape Port Charles forever. From a miraculous resurrection to heartbreaking goodbyes and explosive secrets, viewers are in for one of the most emotionally charged and thrilling weeks in GH history.


Nathan West Lives: A Hero’s Resurrection or a Dangerous Enigma?

In one of the most jaw-dropping returns the soap has ever staged, Nathan West—presumed dead for years—staggers back into Port Charles, disheveled, haunted, and carrying the weight of a dark mystery.

Imagine the visual: rain-soaked streets, flickering streetlights, and a shell-shocked Nathan stepping out of the shadows, barely recognizable but unmistakably alive. This isn’t a simple case of survival—it’s a resurrection shrouded in conspiracy, hinting at experimental procedures, underground labs, and connections to WSB projects that run deeper than anyone dared imagine.

Lulu Spencer will be among the first to confront him, her grief morphing into confusion and suspicion. Britt Westbourne and Professor Henry “Hank” Dalton emerge as key figures in this unfolding drama. Was Nathan part of a covert mission gone wrong—or worse, is he a pawn in a much larger game orchestrated by shadow operatives?

Speculation runs rampant: Did Nathan escape a WSB-controlled facility? Was his death faked as part of an intelligence cover-up? And could the advanced technology used to save him be tied to Britt’s own dramatic “death and rebirth”? Whatever the truth, his return sets the stage for old alliances to shatter and new enemies to rise.


A Farewell to Monica Quartermaine: A Matriarch’s Legacy

As Port Charles reels from Nathan’s reappearance, it is also brought to its knees by the heartbreaking farewell to Monica Quartermaine. The iconic matriarch’s funeral becomes a center of gravity for the community—a rare moment of collective grief that unites feuding family members and estranged loved ones.

The Quartermaine mansion, often filled with scheming and witty barbs, transforms into a chapel of remembrance. Adorned with white lilies and snapshots of Monica’s most iconic moments—her triumphs in the OR, her fiery boardroom debates, and quiet moments with her children—this tribute becomes a celebration of a woman whose strength defined generations.

In a touching tribute to actress Leslie Charleson, a special retrospective montage will air during the service, reminding fans of Monica’s unwavering resilience. As Tracy and Ned deliver tearful eulogies, Erica Slezak debuts in a new, mysterious role—rumored to be Monica’s estranged sister, long believed to have vanished under scandalous circumstances. Could an inheritance dispute or family betrayal resurface from the ashes of Monica’s death?


Drew’s Dilemma: Letting Scout Say Goodbye

The loss of Monica sends Drew Cain spiraling into a fatherly crisis. With court-imposed restrictions limiting Scout’s interactions with certain family members, Drew is forced to decide whether to bend the rules and let his daughter attend her grandmother’s funeral.

Haunted by memories of Monica reading bedtime stories to Scout or offering motherly advice during tough moments, Drew seeks counsel—possibly from Sam McCall, his former flame and Scout’s mother. Their tense interaction may resurface old wounds and raise new questions about trust and co-parenting.

Ultimately, Drew’s choice may lead to one of the week’s most emotionally raw moments—Scout, clutching a child’s drawing, approaching Monica’s casket to say goodbye, a symbol of innocence in a world overrun with secrets and sorrow.


Young Love and Old Ghosts: Emma & Joe’s First Kiss

Amid the chaos, a lighter storyline blossoms as Emma Scorpio-Drake and Giovani “Joe” Palmy finally share their first kiss. Whether it’s under starlight in a local park or during a spontaneous dance at a teen hangout, the moment promises to charm longtime viewers.

Emma, seeking advice from her mother Robin Scorpio, may find herself inspired by tales of Robin’s youthful romances. This new love story serves as a welcome counterpoint to the heavier storylines, exploring the sweet awkwardness of first love and inherited legacy.


Molly’s Literary Obsession: Cody Bell Haunts the Pages

Molly Lansing-Davis dives into her writing to escape lingering feelings for Cody Bell—but the rugged cowboy of her novel is unmistakably Cody in disguise. As her friends begin noticing the parallels, Molly is forced to confront the truth: She may be writing her way into a confession.


Brook Lynn & Lois Reunite in Grief

Monica’s death becomes a catalyst for healing in unexpected places. Brook Lynn Quartermaine finds herself face-to-face with her vibrant, fiery mother Lois Cerullo, whose return to Port Charles brings sunlight into the shadows.

A box of old photos. A vintage guitar. A conversation laced with tears and laughter. Could this be the reconciliation fans have long craved?


Willow’s Web of Deceit: “I Still Love You”

In one of the week’s most manipulative moves, Willow Tait corners Harrison Chase with a whispered confession: “I still love you.” Whether it’s truth or tactic, the impact is immediate and devastating.

As Chase wrestles with his professional duties—sitting on damning evidence that could exonerate Willow and frame Drew—he teeters on the edge of misconduct. Could he be tempted to leak the documents to protect the woman he once loved?

Unbeknownst to him, Willow may be orchestrating the entire situation, using charm and shared memories to pull strings. If she truly is behind a stalking campaign against Daisy Gilmore and a possible attack on Drew Cain, Chase’s loyalty could destroy him.


The Return of Britt Westbourne and Family Fallout

Adding fuel to the emotional inferno is Britt Westbourne’s dramatic return from the grave. Her resurrection tears open old wounds for her mother, Liesl Obrecht, who believed her daughter was lost to the Hook killer.

Instead, Liesl learns Britt orchestrated her own death, sending Liesl into a tailspin of fury and betrayal. In a secluded cabin, Liesl wrestles with memories and the bitter sting of deception.

The shock only intensifies as Nathan’s return threatens to deepen the divide—or heal it. A family reunion staged around secrets, lies, and shattered trust may culminate in a confrontation where Nathan pleads for reconciliation, revealing he too was in hiding, a prisoner of forces darker than anyone imagined.


Maxie in a Coma: Nathan’s Emotional Key?

Maxie Jones lies in a coma, her condition fragile and uncertain. Nathan’s return might be the key to her awakening—or a trigger for further decline. A secret bedside visit from Nathan, where he whispers their shared history and long-lost memories, could mark a turning point.


The Bigger Picture: Caesar Faison’s Shadow Returns

As Anna Devane’s investigation deepens, suspicions arise that Caesar Faison’s legacy is far from over. His grotesque experiments, mind-control tactics, and manipulations may be the sinister thread connecting Britt, Nathan, and the underground labs.

Could Nathan be another of Faison’s victims, manipulated into returning as a different man?


What’s Next for Port Charles?

With secrets boiling to the surface, alliances crumbling, and once-dead characters walking among the living, the week of September 22–26 promises to be one of General Hospital’s most explosive chapters yet.

Will Nathan’s return bring healing or heartbreak?
Can Willow manipulate her way back into Chase’s life—and at what cost?
And as Monica’s legacy echoes through the halls of the Quartermaine mansion, who will rise to fill her shoes?

Stay tuned.


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